Six patients who withdrew consent were not included in the analysis. ResultsĪ total of 410 patients from 28 French centers were randomly assigned to receive antibiotic therapy for 6 weeks (205 patients) or for 12 weeks (205 patients). Noninferiority of 6 weeks of therapy to 12 weeks of therapy would be shown if the upper boundary of the 95% confidence interval for the absolute between-group difference (the value in the 6-week group minus the value in the 12-week group) in the percentage of patients with persistent infection within 2 years was not greater than 10 percentage points. The primary outcome was persistent infection (defined as the persistence or recurrence of infection with the initial causative bacteria, with an antibiotic susceptibility pattern that was phenotypically indistinguishable from that at enrollment) within 2 years after the completion of antibiotic therapy.
Dair procedure trial#
We performed an open-label, randomized, controlled, noninferiority trial to compare 6 weeks with 12 weeks of antibiotic therapy in patients with microbiologically confirmed prosthetic joint infection that had been managed with an appropriate surgical procedure. The appropriate duration of antimicrobial therapy for this indication remains unclear. The management of prosthetic joint infection usually consists of a combination of surgery and antimicrobial therapy. Original Article Antibiotic Therapy for 6 or 12 Weeks for Prosthetic Joint Infection List of authors. The most trusted, influential source of new medical knowledge and clinical best practices in the world.
Dair procedure license#
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